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Ext.NET - ASP.NET (Web Forms + MVC) component framework
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MediaElement.js - HTML5 video and audio unification framework
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Sinon.JS - Standalone test fakes, spies, stubs and mocks for JavaScript. Works with any unit testing framework.
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Enyo JavaScript Application Framework
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Turn.js: The page flip effect in HTML5
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Sequence.js - The responsive CSS animation framework
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Chart.js | Open source HTML5 Charts for your website